摘  要：为了减小夹角余弦法或相关系数法在色谱指纹图谱分析中的误差，提出了峰面积权值非均一性进行相似度计算的新方法。夹角余弦法或相关系数法在色谱指纹图谱分析中存在一定的局限性，通过一个实例及折线图可以看出此二方法与现实情况不相符，另则此二方法对浓度的变化不敏感，对计算结果带来较大的误差。夹角余弦法、相关系数法与数据线性比例没有关系，化学成分比例不变，但其总量变化，则此二者难以体现这种变化；新的算法够体现这种化学成分比例的变化，新方法适合于与总量有关的中药与香精香料的质量分析。   关键词：香精香料；指纹图谱；相似度；质量控制；化学计量学   中图分类号：O242.1；TP751        文献标识码：A          文章编号：1672-4984（2008）03-0141-04   Research on calculation of similarity of fingerprint chromatogram   YANG Zhong-min1， Li Zhong-min1， ZHAO Yue-li1， DENG Lai-hong2， ZONG Zhao-qi1， ZHAO An3   （1.China Tobacco Shandong Industrial Corporation Technical Station of Tengzhou，Tengzhou 277500，China； 2.China Tobacco Shandong Industrial Corporation，Jinan 250013，China； 3.China Tobaceo Shandong Industrial Technical Station of Qingzhou，Qingzhou 262500，China）   Abstract： In order to reduce error of vectorial angle method or the correlation method in the chromatographic fingerprints analysis， a new method on calculation of similarity that assign the different weight according to different size of the peak area was proposed. Vectorial angle method or correlation method has certain limitation in the chromatographic fingerprints analysis. An example and fold line chart proved that they do not conform to the reality. Moreover， the two methods are insensitive to the thickness change and they brings large errors to the computed result. Vectorial angle method and correlation method do not have the relations with the data linearity. Chemical composition’s proportion does not change but its total quantity changes and they are very difficult to display these changes. The new method can do these and it suits in chromatographic fingerprints analysis of the traditional Chinese medicine and the essence spice.   Key words： Flavor and perfume； Chromatogram fingerprint； Similarity； Quality control； Chemic-metrology   Editor：liyan